マイクロチューブ内におけるBSA単分散溶液流れの抵抗低減効果

概要

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In recent biological and chemical analysis fields, micro analytical chips are attracted attention because of some advantages such as high efficiency, small heat capacity and high speed reaction. In those chips, bio-chemical reagents and samples are flown and immobilized on the channel wall. The mechanisms of the flow can not be understood by conventional studies. In this paper, the mechanisms are investigated with the pressure drop measurements of BSA (Bovine Serum Albumin, general protein in analytical fields) dispersed solution flow in microtubes with three kinds of surfaces [glass, PEEK (Poly-Ether-Ether-Ketone) and Hirec-X 1 (highly water repellent agent, NTT-AT co.)] which have different properties. In case of BSA solution flow on the Hirec-X 1 and PEEK surface, results show reduction of friction factor. On the other hand, in case of non BSA solution flow on any surface, results agreed well with Hagen-Poiseuille equation. Furthermore, reduction ratio of friction factor depends on the concentration of BSA. These results imply that the interaction of wall and biomolecules influences flow behavior in microtubes.
社団法人日本機械学会の論文
2006-01-25