D-プシコースは小腸α-グリコシダーゼを阻害し,ラットにおける炭水化物摂取後の血糖値上昇反応を抑制する

概要

論文の詳細を見る
D-Psicose in one of rare sugars present in small quantities in commercial carbohydrates and agricultural products. In this study, we investigate the effects of D-psicose on the activities of α-amylases and α-glucosidases in vitro, and evaluate the effects of D-psicose on postprandial glycemic response using rats in vivo. In vitro study, D-psicose potently inhibited intestinal sucrase and maltase. however, slightly inhibited intestinal and salivary α-amylase activities. Male Wistar rats (6 months old) were administrated 2 g/kg of sucrose, maltose or soluble starch together with 0.2 g/kg of D-psicose or D-fructose. D-Psicose significantly inhibited the increment of plasma glucose concentration induced by sucrose or maltose. Starch-induced glycemic response tended to be suppressed by D-psicose, however the suppression was not significant. These results suggest that D-psicose inhibits intestinal sucrase and maltase activities in an uncompetitive manner and suppresses the plasma glucose increase after sucrose and maltose ingestion. Thus, D-psicose may be useful in proventing postprandial hyperglycemia in diabetic patients when foods containing sucrose and maltose are ingested.
香川大学の論文
2006-02-15