高齢化モデルラットにおける自発的クライミング運動と負荷スイミング運動による筋肉および骨減弱化抑制効果の比較

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We studied the restrictive effects of sarcopenia and osteopenia with voluntary climbing (resistance training) or forced swimming (aerobic training) on rats given glucocorticoid-injections as model of aging. Forty-two male Wistar rats of 5 weeks age were adapted voluntary climbing exercise for 4 weeks. At 9 weeks age, rats were divided into 5 groups. Four group of them were injected subcutaneously glucocorticoid (2 mg/kg). The other group was injected saline as a control (N). The N and one of the glucocorticoid-injected groups (GR) were sedentary, and the other groups were exercised (GC, GS, GCS) for 8 weeks. The GC and GCS groups were climbed, and the GS and GCS groups were forced swimming for an hour. The climbing groups were restricted sarcopenia and osteopenia by glucocorticoid-injected. The swimming groups were tended to inhibit loss of muscle and bone mass. However, swimming groups were decreased weight gain as compared with the other groups. In conclusion, we suggest that moderate resistance exercise would restrict sarcopenia and osteopenia by aging. While aerobic training could decrease body fat accumulation, restrictive effects of sarcopenia and osteopenia were a little.
2009-02-25