1,3-Diphenyl-5-(2-dimethylaminopropionamido)pyrazoleの消化管吸収および生体内分布について

概要

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Examinations were made on the absorption through the digestive tract and systemic distribution of 1,3-diphenyl-5-(2-dimethylaminopropionamido) pyrazole hydrochloride (AP-14・HCl) using rats and the following results were obtained. AP-14・HCl is well absorbed through the digestive tract and 90% of the amount administered is absorbed within 2 hr after its oral administration. This absorption is mainly made through the small intestine and it was thought that this easy absorptivity is due to the high oil/water distribution ratio in the intestinal wall and because this chemical dissolves inside the small intestinal wall. Blood level of AP-14 is low, probably because it has little ability to bind with serum proteins. AP-14 also transits rapidly to fat tissues. Duration of the analgesic effect of AP-14 was found to parallel the concentration of AP-14 in the brain.
公益社団法人日本薬学会の論文
1970-07-25