糖アルコール誘発下痢時における組織内Serotonin, Histamine, Polyamineの変動

概要

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Effects of sugar alcohols on the motility, the fluid movement, the permeability of mesentric blood vessel and the biogenic amines (serotonin (5-HT), histamine (His) and polyamines) in the small intestine of mice were investigated. Diarrhea was induced by oral administration of sugar alcohols (erythritol, arabitol, xylitol, sorbitol, mannitol, maltitol and lactositol) in mice. It is suggested that the acceleration of intestinal motility, the suppression of intestinal fluid movement, the facilitation of mesentric blood vessel permeability and the decrease of substances transport were closely related to the occurrences of diarrhea after ingestion of sugar alcohols. These actions may be mediated by biogenic amines, 5-HT, His and polyamines in the small intestine.
公益社団法人日本薬学会の論文
1981-06-25