ストレプトゾトシン誘発糖尿病性白内障ラットに対するマムシの影響

概要

論文の詳細を見る
Generally accepted etiology of diabetic cataract is the conversion of glucose and galactose into polyol by aldose reductase and the accumulation of polyol in lens to opacity the lens. In experimental diabetic cataract rats the cause is the hyperoxidation of lens membrane by increased active oxigen and lipid peroxide in lens. In the present study, we measured the antioxidant (glutathione) and lipid peroxide (LPO) levels in lens, aqueous humor and vitreous body of rats with streptozotocin (STZ) cataract and studied the effect of Agkistrodon blomhffii blomhffii BOIE. (ABB) on these levels. In STZ diabetes rats, ABB administration reduced the increased LPO levels in lens, aqueous humor and serum and increased the decreased level of glutathione in lens. These results suggested that ABB might be an effective agent for diabetic cataract.
日本生薬学会の論文
1997-04-20