自然発症糖尿病ラット(GKラット)に対する桑葉の抗糖尿病作用

概要

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The antidiabetic effect of hot water extracts from Folium Mori was investigated in GK rat, one of the animal models of non-insulin dependent diabetic mellitus types. Folium Mori extracts(150 mg/kg) significantly reduced the blood glucose of GK rat from 203.8±29.8 to 138.5±21.2 mg/dl at 14 days after oral administration. However, in normal rats, blood glucose and insulin levels were not changed by treatment with Folium Mori. The Folium Mori also decreased blood glucose and improved glucosa tolerance at 14 days after repeated administration in GK rats. The Folium Mori treatment significantly increased glucose metabolism in the gluocose clamp test for GK rats. These results suggest that Folium Mori has quite unique properties such as raising insulin sensitivity and improving insulin resistance.
公益社団法人日本薬学会の論文
2001-05-01