Thyroxine投与ラットの小腸粘膜諸酵素の変動

概要

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Enzyme activities and ultrastructural changes in the small intestinal mucosa of thyroxinetreated rats were investigated. Wistar male rats (8 weeks) were treated with thyroxine 3.0mg/kg/d i.p. for 5 or 10d. Other rats were treated with thyroxine for 10d, followed by taking rest for 10 d. Activities of maltase, alkaline phosphatase, Na^+-K^+-adenosine triphosphatase (Na^+-K^+-ATPase), rotenone insensitive nicotineamide adenine dinucleotidecytochrome c reductase, succinate cytochrome c reductase, nicotineamide adenine dinucleotide phosphate-cytochrome c reductase (NADPH-cyt. c red.) increased in the thyroxine treated rats. On the contrary, the activities of lactase, sucrase, β-glucuronidase, glucose-6-phosphatase (G-6-Pase), β-naphthyl acetate esterase and aspirin esterase decreased in the thyroxine treated rats. Effects on these enzymes by thyroxine were more marked in the 5 d-treated rats than in the 10 d-treated rats except Na^+-K^+-ATPase, and were the same to control in the 10 d-treated and 10 d-rested rats except NADPH-cytochrome c reductase and G-6-Pase. Microvilli of small intestinal epithelium were thick and low, and mitochondria, gER, Golgi apparatuses and free ribosomes of the epithelial cells increased in the thyroxine treated rats. Therefore it is suggested that thyroxine affects the absorption of drugs.
公益社団法人日本薬学会の論文
1983-09-25