薬物の併用に関する研究(第5報) : アモバルビタールおよびペントバルビタールの肝酵素系における代謝におよぼす4-オキシアンチピリンの影響

概要

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When 4-hydroxyantipyrine (HOAT), being the metabolites of aminopyrine and antipyrine, was used together with the soporifics of pyrazolone series of anesthetics, amobarbital or pentobarbital, the metabolism of amobarbital in rat liver slices, and the supernatant of 9000×g fraction of rat and rabbit livers were promoted and the biological half-life was found to be shortened. On the other hand, the metabolsim of pentobarbital, to which being resemble in structure, was suppressed and the biological half-life was also lengthened, and the reverse results to amobarbital has been observed. When HOAT was given 30 min prior to the amobarbital administration, the sleeping period of mice was found to be less shortened than the case amobarbital was administered alone.
公益社団法人日本薬学会の論文
1968-07-25