鎮痛薬の研究(第7報) : CocaineとAmphetamineのMorphine鎮痛増強作用の違いについて

概要

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Difference in the potentiative action of amphetamine and cocaine in increasing the analgesic effect of morphine was examined by the hot-plate method and pressure-stimulation method in mice. Amphetamine and cocaine themselves did not show any analgesic effect but both potentiated that of morphine. Administration of reserpine or Tetrabenazine, followed by dl-DOPA, and then by morphine indicated that the analgesic effect of morphine returned to the value of that with single administration of morphine. Administration of tetrabenazine, followed by amphetamine and morphine resulted in potentiation of the analgesic effect of morphine but not when morphine was administered with cocaine. However, when administration of tetrabenazine and then dl-DOPA was followed by simultaneous administration of cocaine and morphine, potentiation of analgesic effect of morphine was observed, as in the case of cocaine and morphine alone.
公益社団法人日本薬学会の論文
1971-03-25