ヨードヒスチジンの代謝(第1報)ジョードおよびモノヨードヒスチジンの脱ヨード化反応の比較研究

概要

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Behavior of deiodination of diiodohistidine (DIH) in the presence of liver and kidney homogenates of the rat was studied qualitatively in terms of time course on thin layer chromatography and paper chromatography comparing with the known course of metabolism of diiodotyrosine (DIT) . Differing from DIT, iodine was split from DIH depending neither on the amount of homogenate or time course. In order to examine the mode of deiodination from DIH and monoiodohistidine (MIH) more precisely, they were labeled with ^<131>I, and the metabolism of DIH and MIH was found to be considerably different : 1) Deiodination of DIH occurred partly non-enzymically, and proceeded only by incubation of the aqueous solution at 37°, and the rate of deiodination increased to some extent by the addition of the thyroid gland, liver, or kidney homogenate to the solution. 2) On the other hand, MIH was not deiodinated by a short-time incubation (up to 2 hr) of the aqueous solution with the thyroid gland, liver, or kidney homogenate. MIH was then administered to intact rats to detect any metabolites. Radioactive iodide began to appear in the urine 24 hr after the subcutaneous administration of MIH. It may be concluded from the present study that DIH is deiodinated enzymically and non-enzymically, but MIT resists rapid metabolism, and it is deiodinated slowly in the body.
社団法人日本薬学会の論文
1975-06-25