Changes in Arylsulfatase Activity in Experimental Allergic Encephalomyelitis (II):Correlation between Experimental Allergic Encephalomyelitis and Arylsulfatase-A Activity

概要

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Changes in the arylsulfatase (AS) activity in the brain were detected in the experimental allergic encephalomyelitis (EAE) using ascorbate-2-sulfate (AAS) as a natural substrate for AS-A. Catecholamine (CA) levels in the brain in EAE rats were also detected. It was found as the results that 1) AS-A hydrolyzing a natural substrate AAS, was not different in the EAE rats from the normal ones. 2) Total AS hydrolyzing a synthetic substrate, 4-methylumbelliferyl sulfate (4-MUS), increased after EAE indction. 3) Only norepinephrine (NE) level among CA levels of the brain in the EAE rats was specifically lower. 4) It may be assumed that only AS-B incrases in the EAE rats, and the disturbance of nor-adrenargic nervous functions can be ascribable to these phenomena.
Japan Society of Clinical Chemistryの論文