Pyridazines. XI. Pyrido[2,3-d]pyridazines. II

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概要

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• 8-Oxo-7,8-dihydropyrido[2,3-d]pyridazine-5-carboxylic acid, 7-phenyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazine-5-carboxylic acid, and their esters, amides and hydrazides were prepared. Alkaline hydrolysis of 7-phenyl-8-oxo-7,8-dihydroprido[2,3-d]pyridazine-5-carboxylates gave phenylhydrazone of 3-formylpicolinic acid and good yields of 3-(2-carbamoyl)pyridylglyoxylates. Reaction of quinolinic anhydride with 2 molar equivalents of phenylhydrazine in acetic acid gave the cyclized phenylhydrazide, and its structure, 5-hydroxy-7-phenylpyrido[2,3-d]pyridazin-8(7H)-one, was determined by its chlorination followed by catalytic hydrogenation to give 7-phenyl-1,2,3,4-tetrahydropyrido[2,3-d]pyridazin-8(7H)-one. 6,7-Diphenylpyrido[2,3-d]pyridazine-5,8(6H, 7H)-dione was also prepared.

• 公益社団法人日本薬学会の論文
• 1966-09-25

著者

• 新田 義博

  Research Laboratory, Chugai Pharmaceutical Co., Ltd.

• 米田 文郎

  Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• 新田 義博

  Shizuoka College Of Pharmacy

• 松浦 育敏

  Research Laboratories Chugai Pharmaceutical Co. Ltd.

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