The Syntheses of Some Aminomethylindoles

スポンサーリンク

概要

• 論文の詳細を見る

• By treating with secondary amines chloraceto-o-toluidide was converted to aminoaceto-o-toluidides, which were cyclized on heating with sodium amide to give 2-aminomethylindoles. N-Benzyl-N-(N, N-dimethylaminoaceto)-o-toluidide on treatment with sodium amide was converted to 1-benzyl-2-N, N-dimethylaminomethylindole. N-Benzyl-(or N-p-chlorobenzyl-) N-phenylhydrazine was treated with aminoacetones in the presence of a trace of acetic acid to convert the corresponding aminoacetone N-benzyl-(or N-p-chlorobenzyl-) N-phenylhydrazones. The indole cyclization of the latter gave 1-benzyl-2-methyl-3-aminoindoles. On treatment of aminoacetones with phenylhydrazine derivatives in ethyl alcohol, methylglyoxal diphenylhydrazone derivatives were obtained.

• 公益社団法人日本薬学会の論文
• 1967-01-25

著者

• 新田 義博

  Research Laboratory, Chugai Pharmaceutical Co., Ltd.

• 米田 文郎

  Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• 新田 義博

  Shizuoka College Of Pharmacy

• 宮前 卓之

  Research Laboratories Chugai Pharmaceutical Co. Ltd.

関連論文

• スルホンアミド類の合成研究(第3報)1,2,4-Benzothiadiazine 1,1-Dioxide類の合成
• Studies on Steroids. II. The Preparation and Properties of 17β-(N-Substituted 2-Amino-4-thiazolyl) androst-4-en-3β, 17α-diol Series and its Hydrogen Succinate.
• Studies on Steroids. I. The Preparation and Properties of 17β-(N-Substituted 2-Amino-4-thiazolyl)-androst-4-en-3-one Series.
• D-Glucarolactone誘導体の研究(第2報) : O-Benzylidene-D-glucarolactoneの構造とアミンの反応
• D-グルカロラクトンとアミンの反応
• Pyrimidine Derivatives. III. The Preparation and Bacteriostatic Activity of Benzamidopyrimidines
• ビリダジン誘導体(第9報) : 2,3-ジアザフェノチアジン誘導体の合成
• Pyridazine Derivatives. X. 10H-Benzo[b]pyridazino[3,4-e][1,4]thiazine and 5H-Benao[b]pyridazino[4,3-e][1,4]thiazine
• Pyridazine Derivatives. VII. Syntheses of 1,2- and 2,3-Diazaphenothiazines
• Pyridazin-derivate. VI. Synthese der Derivate des Imidazo [1,2-b] pyridazins
• Pyridazin-derivate. V. Synthese der Derivate des 6-Phenyl-3 (2H)-pyridazinons.
• 10H-Benz [b] pyridazino [3,4-e] [1,4] thiazin und 5H-Benz [b] pyridazino [4,3-e] [1,4] thiazin
• Pyridazinderivate. III. Synthese der Anilinopyridazine.
• Studies on Analgesics of Aniline Series. III. Preparation and Properties of N, N-Dialkyl 3-(Substituted anilino) butyramide Series
• Studies on Analgesics of Aniline Series. II. Preparation and Properties of N-Alkyl or N, N-Dialkyl 3-(N'-Acyl- or N'-Benzyl-substituted anilino) propionamide Series and N-Alkyl or N, N-Dialkyl 3-(Substituted anilino) propylamine Series
• Studies on Analgesics of Aniline Series. I. Preparation and Properties of β-Alaninamide Series
• Studies on Steroids. III. The Preparation of Steroid-21-yl-glucopyranosiduronamides.
• D-Glucuronolactone Derivatives. VII. Synthesis of Anomeric 1-Deoxy-1-halogeno-2,5-di-O-acyl-D-glucofuranurono-γ-lactones
• Glucuronosideの加水分解に関する研究(第4報) : Glucofuranosidurono-3,6-lactoneとGlucopyranosiduronic Acidおよびそれらのα-, β-Anomerの酸およびアルカリによる加水分解
• Glucuronosideの加水分解に関する研究(第1報) : β-D-Glucopyranosiduronic Acidの酸触媒反応
• Studies on Oxidized Starch Sulfates for Medical Purposes. I. Synthesis of Sulfates of Oxidized Starch and its Derivatives.
• ピペラジン誘導体の研究(第1報) : 2-Phenylpiperazine誘導体の合成およびその薬理作用
• ピペラジン誘導体の研究(第6報) : 2-Phenylpiperazine誘導体の抗ヒスタミンおよび抗アセチルコリン作用
• ピペラジン誘導体の研究(第2報) : Piperazinoalkylbarbituric Acid誘導体の合成およびその薬理作用
• Studies on Sulfonylurea Derivatives. III. The Infrared Spectra of 1-p-Tolylthio-3-alkylureas and Corresponding Sulfonyl Compounds.
• Derivees des Pyrimidines. II. Synthese des Alcocy-2-Pyrimidyl-4)-N^1-Sulfanilamides
• Pyrimidine Derivatives. I. Synthesis of a New Series of Sulfanilamides having Dialkylamino Groups in the Pyrimidine Nucleus
• Pyridazines. XI. Pyrido[2,3-d]pyridazines. II
• Pyridazine Derivatives. VIII. Pyrido[2,3-d]pyridazines. I.
• The Syntheses of Some Aminomethylindoles
• Synthese der 1,2,3,4-Tetrahydrochinolin-derivate
• Synthesis of Imidazo [4,5-e]-as-triazine (6-Azapurine) Derivatives
• Electronic Structure and Local Anesthetic Activity of 2-Diethylaminoacetanilide Derivatives
• Electronic Structure and Antibacterial Activity of Nitrofuran Derivatives
• Pyridazine Derivatives. IV. The Structures of Aminopyridazines.
• Pyridazine Derivatives. II. Infrared Spectra of O-, N-Mono- and O, N-Dibenzyl Compounds of Maleic Hydrazide.
• Pyridazin-derivate. I. Synthese der Derivate des Oxypyridazins.
• Einwirkungen von Essigsaureanhydrid auf Pyridazin-N-oxyden

もっと見る 閉じる

スポンサーリンク