ピペラジン誘導体の研究(第1報) : 2-Phenylpiperazine誘導体の合成およびその薬理作用
スポンサーリンク
概要
- 論文の詳細を見る
Introduction of 2-hydroxyethyl group into the nitrogen in 1-phenyl-2-aminoethanol derivative (III-1-3), and dl-and l-ephedrine hydrochlorides afforded dihydroxy compounds (IV-1-4 and VIII) which were chlorinated into a nitrogen mustard-type dichloro compounds (V-1-4 and IX), and the latter were reacted with primary amine (VI) to obtain 2-phenylpiperazine derivatives (VII-1-19 and X-1-2), (+)-1-(p-chlorobenzyl)-2-phenyl-3,4-dimethylpiperazine (X-1) was prepared by the chlorination of l-ephedrine hydrochloride to L-(+)-threo-chloro compound (XI), its reaction with a primary amine to obtain(+)-diamino compound (XII), and treatment of XII with dibromoethane. The compounds so obtained were tested for increasing the coronary and peripheral (femoral artery) blood flow using dogs. Some nine of the compounds tested were found to increase coronary blood flow, more than three times that of aminophylline used as the control. Some considerations were also made on the relationship between chemical structure and pharmacological activity.
- 公益社団法人日本薬学会の論文
- 1969-05-25
著者
関連論文
- スルホンアミド類の合成研究(第3報)1,2,4-Benzothiadiazine 1,1-Dioxide類の合成
- D-Glucarolactone誘導体の研究(第2報) : O-Benzylidene-D-glucarolactoneの構造とアミンの反応
- D-グルカロラクトンとアミンの反応
- Pyrimidine Derivatives. III. The Preparation and Bacteriostatic Activity of Benzamidopyrimidines
- ビリダジン誘導体(第9報) : 2,3-ジアザフェノチアジン誘導体の合成
- Pyridazine Derivatives. X. 10H-Benzo[b]pyridazino[3,4-e][1,4]thiazine and 5H-Benao[b]pyridazino[4,3-e][1,4]thiazine
- Pyridazine Derivatives. VII. Syntheses of 1,2- and 2,3-Diazaphenothiazines
- Pyridazin-derivate. VI. Synthese der Derivate des Imidazo [1,2-b] pyridazins
- Pyridazin-derivate. V. Synthese der Derivate des 6-Phenyl-3 (2H)-pyridazinons.
- 10H-Benz [b] pyridazino [3,4-e] [1,4] thiazin und 5H-Benz [b] pyridazino [4,3-e] [1,4] thiazin
- Pyridazinderivate. III. Synthese der Anilinopyridazine.
- ビペラジン誘導体の研究(第5報) : 7-{2-Hydroxy-3-[4-(p-chlorobenzyl)-piperazino]propyl}theophyllineの循環系に対する作用
- Glucuronosideの加水分解に関する研究(第4報) : Glucofuranosidurono-3,6-lactoneとGlucopyranosiduronic Acidおよびそれらのα-, β-Anomerの酸およびアルカリによる加水分解
- Glucuronosideの加水分解に関する研究(第1報) : β-D-Glucopyranosiduronic Acidの酸触媒反応
- Studies on Oxidized Starch Sulfates for Medical Purposes. I. Synthesis of Sulfates of Oxidized Starch and its Derivatives.
- ピペラジン誘導体の研究(第1報) : 2-Phenylpiperazine誘導体の合成およびその薬理作用
- ピペラジン誘導体の研究(第6報) : 2-Phenylpiperazine誘導体の抗ヒスタミンおよび抗アセチルコリン作用
- ピペラジン誘導体の研究(第4報) : Piperazinoalkyltheophylline誘導体の冠および肢血流に対する作用
- ピペラジン誘導体の研究(第3報) : Piperazinoalkyltheophylline誘導体の合成
- ピペラジン誘導体の研究(第2報) : Piperazinoalkylbarbituric Acid誘導体の合成およびその薬理作用
- Pyridazines. XI. Pyrido[2,3-d]pyridazines. II
- Pyridazine Derivatives. VIII. Pyrido[2,3-d]pyridazines. I.
- The Syntheses of Some Aminomethylindoles
- Synthese der 1,2,3,4-Tetrahydrochinolin-derivate
- Synthesis of Imidazo [4,5-e]-as-triazine (6-Azapurine) Derivatives
- Electronic Structure and Local Anesthetic Activity of 2-Diethylaminoacetanilide Derivatives
- Electronic Structure and Antibacterial Activity of Nitrofuran Derivatives
- Pyridazine Derivatives. IV. The Structures of Aminopyridazines.
- Pyridazine Derivatives. II. Infrared Spectra of O-, N-Mono- and O, N-Dibenzyl Compounds of Maleic Hydrazide.
- Pyridazin-derivate. I. Synthese der Derivate des Oxypyridazins.
- Einwirkungen von Essigsaureanhydrid auf Pyridazin-N-oxyden