ピペラジン誘導体の研究(第2報) : Piperazinoalkylbarbituric Acid誘導体の合成およびその薬理作用

概要

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Piperazinoalkylbarbituric acid derivatives (VIII, IX, and X) were prepared by the introduction of phenobarbital and allobarbital into 1-and 1,3-position of substituted piperazines with ethylene, propylene, and β-hydroxypropylene as the bonding bridge. These derivatives were obtained by the reaction of barbituric acid with unsymmetrically 1,4-disubstituted piperazines having a functional group in the ω-position. Phenobarbital series compounds with ethylene as the bonding bridge were obtained by the reaction of 1-(2-bromoethyl)-5-ethyl-5-phenylbarbituric acid (VII) and monosubstituted piperazines. The compounds so obtained were tested for prolonged duration of hexobarbital sodium anesthesia, using mice, and general symptoms in mice was tested with two compounds by their intraperitoneal administration. Correlation between chemical structure and pharmacological activity was examined from these results.
公益社団法人日本薬学会の論文
1969-05-25