ビペラジン誘導体の研究(第5報) : 7-{2-Hydroxy-3-[4-(p-chlorobenzyl)-piperazino]propyl}theophyllineの循環系に対する作用

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Pharmacological examinations were made on the action of 7-{2-hydroxy-3-[4-(p-chlorobenzyl) piperazino] propyl} theophylline (SP-1131) on the circulation system, using aminophylline as the control agent, with dogs and rats. Intra-arterial and intravenous administration of SP-1131 in coronary and femoral arterial perfusion in a dog elicited strong increase in coronary blood flow and transitory increase in femoral arterial blood flow. Increased flow of coronary arterial blood was markedly observed in heart-lung preparation test. Intravenous administration of SP-1131 resulted in slight variation of blood pressure and increased heart rate in normal and spinal dogs but the action was weaker than that of theophylline. In the constant pressure perfusion experiments with mesenteric artery and renal artery of the dog, SP-1131 increased blood flow when given intra-arterially but decreased renal blood flow when given as an intravenous injection. Experiments with the rat did not show oliguria action. In the heart-lung preparation experiments with the dog, SP-1131 decreased the cardiac minute volume and heart beat, showing that it had no action of myocardial stimulation. Consequently, the mechanism of the action of SP-1131 on blood pressure and increasing heart beat seems to differ in some respects from that of theophylline. It was considered that its action on dilating coronary blood vessels might not be due to the secondary factor accompanying accelerated myocardial metabolism.
公益社団法人日本薬学会の論文
1970-07-25

ビペラジン誘導体の研究(第5報) : 7-{2-Hydroxy-3-[4-(p-chlorobenzyl)-piperazino]propyl}theophyllineの循環系に対する作用

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