1-(p-Chlorophenylsulfonyl)-2-imidazolidinone(CPSI)の血糖上昇機作について(第2報)1-(p-Chlorophenylsulfonyl)-2-imidazolidinone(CPSI)の糖質はらびに脂質代謝に及ぼす影響

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概要

• 論文の詳細を見る

• In a previous paper we have reported that, unlike alloxan, the hyperglycemic action of 1-(p-chlorophenylsulfonyl)-2-imidazolidinone (CPSI) might be induced by its inhibitory effect on the releasing process of insulin from pancreatic β cells. In this paper, influences of CPSI on carbohydrate and lipid metabolism have been investigated comparatively with that of chlorpropamide (P-607). The results obtained were summarized as follows. 1) The muscular and liver glycogen levels in rats were both lowered by P-607 (100 mg/kg, p.o.), whereas CPSI (100 mg/kg, p.o.) increased the liver glycogen level and lowered the muscular glycogen level significantly. 2) The serum free fatty acids and triglycerides levels in the fasted rats were both lowered by P-607 (100 mg/kg, p.o.), whereas increased by CPSI (100 mg/kg, p.o.). These phenomenon were markedly manifested when a relatively large quantities of CPSI and P-607 (both 300 mg/kg, p.o.) were dosed to the fed rats. 3) The serum total cholesterol level in the fed rats were lowered by P-607 (300 mg/kg, p.o.), whereas increased by CPSI (300 mg/kg, p.o.). The results obtained seems to give a good explanation for the behavior of the peripheral blood insulin level toward to CPSI and P-607. They may support our suggestion strongly that CPSI have an inhibitory effect on the releasing process of insulin from pancreatic β cells and that P-607 have a stimulatory effect on the same process.

• 公益社団法人日本薬学会の論文
• 1975-07-25

著者

• 山田 澄

  北陸大学薬学部

• 山田 澄

  神戸女子薬科大学

• 中西 一之

  神戸女子薬科大学

• 寺田 護

  神戸女子薬科大学

• 巻幡 希子

  神戸女子薬科大学

• 秦 雅子

  神戸女子薬科大学

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• 1-(p-Chlorophenylsulfonyl)-2-imidazolidinone(CPSI)の血糖上昇機作について(第2報)1-(p-Chlorophenylsulfonyl)-2-imidazolidinone(CPSI)の糖質はらびに脂質代謝に及ぼす影響
• 1-(p-Chlorophenylsulfonyl)-2-imidazolidinone(CPSI)の血糖上昇機作について

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