D-Glucarolactone誘導体の研究(第2報) : O-Benzylidene-D-glucarolactoneの構造とアミンの反応
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概要
- 論文の詳細を見る
From the benzylidene compound of D-glucaro-monolactone monoalkyl ester, its O-methyl compound was synthesized. The hydrolysis product of this O-methyl compound was found to be identical with 5-O-methyl-D-glucarolactone, obtained by the bromine oxidation of known 5-O-methyl-D-glucuronolactone, from which fact it was proved that structure of the benzylidene compound is 2,4-O-benzylidene-D-glucaro-6,3-lactone 1-alkyl ester. Its reaction with ammonia and amines respectively affords 6-amide 1-alkyl ester and 1,6-diamide but, in the case of its 5-O-methyl compound, 1,6-diamide compound is formed more easily and it is difficult to obtained the monoamide compound. Hydrolysis of these amide compounds seems to result in the initial hydrolysis of the acid amide in the 6-position to form the 3,6-lactone and followed by hydrolysis of the benzylidene group.
- 社団法人日本薬学会の論文
- 1966-11-25
著者
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井手 淳二
中外製薬株式会社総合研究所
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高橋 英徳
中外製薬株式会社総合研究所
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井手 淳二
中外製薬研究所
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高橋 英徳
中外製薬研究所
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田浦 新
中外製薬研究所
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新田 義博
中外製薬研究所
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田浦 新
中外製薬株式会社総合研究所
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新田 義博
Shizuoka College Of Pharmacy
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