Pyridazine Derivatives. VII. Syntheses of 1,2- and 2,3-Diazaphenothiazines
スポンサーリンク
概要
- 論文の詳細を見る
3,4,5-Trichloropyridazine on treatment with 2-aminothiophenol gave 4-chloro-10H-benzo[b]pyridazino[3,4-e][1,4]thiazine (II) and 1-chloro-10H-benzo[b]pyridazino[4,5-e][1,4]-thiazine (III). II was converted into 10H-benzo[b]pyridazino[3,4-e][1,4]thiazine by catalytic dechlorination. Treatment of 4,5-dichloro-3-(2H)-pyridazinone with 2-aminothiophenol afforded 5-(2-aminophenylthio)-4-chloro-3(2H)pyridazinone, which was cyclized on heating with potassium carbonate in dimethylformamide to yield 10H-benzo[b]pyridazino[4,5-e][1,4]thiazin-1(2H)-one. Chlorination of the latter with phosphoryl chloride and N, N-dimethylaniline afforded III. Several 2-substituted-10H-benzo[b]-pyridazino[4,5-e][1,4]thiazin-1(2H)-ones were synthesized.
- 公益社団法人日本薬学会の論文
- 1965-05-25
著者
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大高 孝之
中外製薬綜合研究所
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新田 義博
Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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米田 文郎
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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大高 孝之
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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新田 義博
Shizuoka College Of Pharmacy
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