Pyridazine Derivatives. X. 10H-Benzo[b]pyridazino[3,4-e][1,4]thiazine and 5H-Benao[b]pyridazino[4,3-e][1,4]thiazine
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概要
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4-(2-Aminophenylthio)-3,6-dichloropyridazine (I) on treating with dil. Hydrochloric acid or acetic acid gave 3-chloro-5H-benzo[b]pyridazino[4,3-e][1,4]thiazine (3,4-diazapheno-thiazine type) through rearrangement and cyclization. 3-Chloro-10H-benzo[b]pyridazino-[3,4-e][1,4]thiazine (1,2-diazaphenothiazine type) was obtained by either heating of I at 150°or treating of I with conc. hydrochloric acid through direct cyclization. The mechanism of the aforesaid reactions was discussed using a molecular orbital method. Several 1,2-and 3,4-diazaphenothiazine derivatives were synthesized.
- 公益社団法人日本薬学会の論文
- 1966-07-25
著者
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大高 孝之
中外製薬綜合研究所
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新田 義博
Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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米田 文郎
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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大高 孝之
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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新田 義博
Shizuoka College Of Pharmacy
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