Pyridopyridazines. III. Pyrido [3,4-d] pyridazines. I.

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概要

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• Improved syntheses of 1,4-dihydroxypyrido [3,4-d] pyridazine (II) and 1,4-dichloropyrido [3,4-d] pyridazine (I) were described. Reaction of I with alcohol and alkali gave 1,4-dialkoxypyrido [3,4-d] pyridazines (IIIa-c). Hydrolysis of I gave an isomeric mixture of 1-chloro-4-hydroxy- and 1-hydroxy-4-chloropyrido [3,4-d] pyridazines (IV and V). Reaction of I with hydrazine hydrate afforded also an isomeric mixture of 1-chloro-4-hydrazino- and 1-hydrazino-4-chloropyrido [3,4-d] pyridazines (VIII and IX). The structures of these compounds were determined by an alternative synthesis of V from known 1-hydroxy-4-aminopyrido [3,4-d] pyridazine (VI) and by conversion of IX into V. Also described were the preparations of 1-hydroxypyrido [3,4-d] pyridazine (VII) and isopropylidene derivatives (X and XI) of VIII and IX, and improved syntheses of 1,4-dichlorophthalazine and ethyl 3-cyanoisonicotinate.

• 公益社団法人日本薬学会の論文
• 1969-11-25

著者

• 奥井 清

  Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• 奥井 清

  Research Laboratories Chugai Pharmaceutical Co. Ltd.

• 松浦 育敏

  Research Laboratories Chugai Pharmaceutical Co. Ltd.

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• Pyrimidine Derivatives. I. Synthesis of a New Series of Sulfanilamides having Dialkylamino Groups in the Pyrimidine Nucleus
• Pyridopyridazines. III. Pyrido [3,4-d] pyridazines. I.
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