Azabenzomorphane and Related Compounds. II. A Synthesis of 1,2,3,4-Tetrahydro-6H-1,5-methanobenzo[f][1,4]diazocine
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概要
- 論文の詳細を見る
In order to test the analgesic action of 2,3,4,5-tetrahydro-6H-1,5-methanobenzo-[f][1,4]diazocine (III), methods for its synthesis were examined using various starting materials. Compounds (XIII, XVI, and XVII) were synthesized from isoquinoline (IV) via 4-aminoisoquinoline (VI). Cyclization of compounds (XIII, XVI, and XVII) gave the objective azabenzomorphane derivatives (XIV, III, and XVIII), respectively. Reduction of lactam (XVIII) with lithium aluminum hydride and debenzylation of XIV by catalytic hydrogenation in the presence of Adam's platinum afforded the same objective compound (III), which was also recognized as benzoyl and acetyl derivatives (XIV and XX).
- 公益社団法人日本薬学会の論文
- 1965-03-25
著者
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柊木 峯治
グレラン製薬株式会社研究所
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亀谷 哲治
Pharmaceutical Institute Medical Faculty University Of Osaka
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気賀沢 和雄
Pharmaceutical Institute, Tohoku University School of Medicine
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石丸 春秀
Research Laboratories, Grelan Pharmaceutical Company, Ltd.
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柊木 峯治
Pharmaceutical Institute, Tohoku University School of Medicine
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石丸 春秀
Research Laboratories Grelan Pharmaceutical Company Ltd.
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