Azabenzomorphane and Related Compounds. VII. Synthesis of 1,2,3,4,5,6-Hexahydro-2,6-methanobenzo [d][1,3] diazocine Derivatives
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概要
- 論文の詳細を見る
In order to test the analgesic action of 1-methl-(XIa) and 1,3-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methanobenzo [d][1,3] diazocine (XIb) were synthesized from 1-methyl-4-carboxymethylcarbostyril (III) as a starting material. Reductive cyclization of Xa and Xb with metallic sodium in ethanol gave, respectively, the expected azabenzomorphane derivatives, XIa and XIb. Furthermore, Ladenburg reduction of 1-methyl-4-carba-moylmethylcarbostyri (XII) also gave the above compound (XIa).
- 公益社団法人日本薬学会の論文
- 1965-10-25
著者
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柊木 峯治
グレラン製薬株式会社研究所
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亀谷 哲治
Pharmaceutical Institute Medical Faculty University Of Osaka
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気賀沢 和雄
Pharmaceutical Institute, Tohoku University School of Medicine
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柊木 峯治
Research Laboratories, Grelan Pharmaceutical Company, Ltd.
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