腎腫瘍に対する制癌剤の腎動脈内持続注入療法

概要

論文の詳細を見る
In an effort to enhance the anti-tumor effect of drug therapy and at the same time lessen side effects thereof in the treatment of renal neoplasms, an attempt was made to administer anti-cancer drugs by continuous infusion into the renal artery. 1) Five cases with carcinoma of the renal parenchyma received treatment with an anti-cancer drug infused into the renal artery in a continuous manner through a catheter which beforehand was inserted into the artery and held there after Seldinger technique. The anti-cancer drug used was 5-fluorouracil, which was administered continuously over a 14-day period at a dosage of 500mg daily, hence in a total dose of 7000mg. Two of these 5 cases were given, in addition to the above medication, 3 doses of 10mg mitomycin C by one shot injection into the renal artery. 2) In all of 3 cases with a palpable tumor initially, out of the 5 thus treated, the tumor was found shrunk in size on palpation after therapy. The therapy was also associated with an appreciable reduction in tortuosity of blood vessels as well as in puddling of the contrast agent in the vascular sinuses on renal arteriography in 3 of the 5 cases. Histological examination of the growth following nephrectomy, which was feasible in 4 cases, revealed swelling and irregular boundaries of tumor cells along with karyorrhexis and pyknosis. Further noticeable changes included necrosis, which was seen to be extensive and diffuse in 2 cases and partial in another, and hemorrhage which was predominant in the remaining one case.
社団法人日本泌尿器科学会の論文

腎腫瘍に対する制癌剤の腎動脈内持続注入療法

スポンサーリンク

概要

著者

関連論文

スポンサーリンク