^<99m>Tc-DMSAによる腎スキャンの臨床的検討

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In the past, ^<208>Hg-Neohydrin was commonly in use as a renal imaging agent. However ^<208>Hg-Neohydrin has such drawbacks as requiring high radiation dose to the patient. In an attempt to overcome this disadvantage, ^<197>Hg-Neohydrin and ^<99m>Tc-labeled renal scanning agents have been evaluated. In this report ^<99m>Tc-dimerucaputosuccinic acid (^<99m>Tc-DMSA: Medi-Physics) was evaluated for the clinical renal imaging. Ninety-seven cases consisted of 53 females and 44 males ranging from 12 to 89 years old (mean 60.4 years old) were studied by this new radiopharmaceutical. Pho/Gamma 4 gamma camera with parallel hole high resolution and pinhole collimators and Graphic 5φ scanner were used. The images were obtained at 30 min, 1, 2, 3, 4 and 6 hours after intravenous injection of 5 mCi of ^<99m>Tc-DMSA. In some cases, radioisotope angiogram was obtained after bolus injection of 10 mCi of ^<99m>Tc-DMSA. In all cases, clear renal images were obtained up to 6 hours after injection. When the pinhole collimator was used in order to enlarge each kidney to full size of the field of view, more detail of renal image could be seen with improved resolution compared with images obtained by parallel collimator or Graphic scanner. When a breath-holding technique is applied it could minimize the image-degrading effect of respiratory movement of the kidneys.
社団法人日本泌尿器科学会の論文
1976-08-20