泌尿器科領域の悪性腫瘍における ferritin 測定の意義 (第一報)

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Serum ferritin was determined in patients with urologic cancer and the relation with other clinical indicator serum CEA and iron was studied. The stability of 2-site immunoradiometric assay for serum ferritin was also studied by recovery test, dilution test and reproducibility. The recovery ratio was excellent, 93% on the average. Commercial control serum NMS-IIa of 306 ng/ml and a stock serum (serum from renal cell carcinoma) of 1808 ng/ml were diluted. The NMS-IIa showed an excellent dilution pattern. However, in the stock serum, the dilution curve revealed so-called "high dose hook effect". The reproducibility was excellent, CV% in test serum and in NMS-II were 9% and 3% respectively. Determination of serum ferritin was performed in 113 patients with various kinds of urologic diseases and 20 cases of normal control. The average of serum ferritin level from male control was 114±43 ng/ml (n=10) and from female control was 57±39 ng/ml (n=10). By this method, the normal range was considered to be below 200 ng/ml in man.
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