Formocresol (FC) の経日変化に関する研究 : 11 起炎性の変化

概要

論文の詳細を見る
For the purpose of studying the progressive change in inflammatory potential of FC, the skin irritative reactions to stale FC was compared with that to fresh FC or stale cresol with use of liquefied phenol as positive control. The samples were fresh FC prepared immediately before the test, four kinds of stale FC and two kinds of stale cresol which had been kept in the various conditions for from 16 to 39 months, liquefied phenol (J.P.) and normal salin solution (J.P.). The skin irritation was tested with application of the sample on the shaved dorsal skin of male rabbits of New Zealand albino strain. The paper disc soaked with 30μl of the sample was sticked on the skin with an adhesive tape for 30 minutes, and then the die solution, 1% Evan's blue, was injected intravenously. The irritative reactions were evaluated according to the intensity of blue eruption formation and cauterization. It was showed that skin irritation to fresh FC was more intense than that to liquefied phenol or that to stale FC stored for the long term. It is presumed that inflammatory potential of FC is dependent on chemical constitution of FC, and that inflammatory potential of FC stored in unsealed containers increases temporarily prior to the rapid decrease while that of FC stored sealed containers decreases gradually.
1981-05-25