ウサギ摘出気管標本における亜硫酸とプロカイン, アスパラギン酸, グルタミン酸合剤の拮抗作用

概要

論文の詳細を見る
A study was undertaken to confirm possible antagonistic action of a mixture consisting of procaine, asparagic and glutamic acids (PAG) against the tissue damage of excised tracheal muscle of rabbit by exprosure to sulfur dioxide solution which is known in its gaseous state as one of the major causative agents of tracheal inflammation and asthma in man. Evidences were presented in this study that contraction of the smooth muscle of trachea to be induced by application of sulfur dioxide solution could be suppressed successfully by preadministration of PAG, and that the muscle which had been contracted by exposure to the agent could be restored to its original state with the administration of PAG by dilating it antagonistically. Determinative studies were further conducted on the amounts of PAG that might be required for complete dilatation of the muscle that had been contracted with varying intensities by exposure to varying amounts of sulfur dioxide solution, and results were presented.
九州歯科学会の論文
1970-05-31