根管治療剤ホルマリン・グアヤコールの局所刺激性

概要

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For the purpose of studying the topical irritation by Formalin-guaiacol (FG) and the minimum causative concentration of it, the skin irritative reactions to FG were compared with those to Formalin-cresol (FC), guaiacol and cresol with use of liquefied phenol (J.P.) as positive control and normal salin solution as negative control. The samples were diluted with olive oil by multiple method prior to application. The paper disc soaked with 30μl of a sample solution was sticked on the shaved dorsal skin of male rabbits of New Zealand White strain with an adhesive tape for 30 minutes and then the die solution, 1% Evan's blue, was injected intravenously. The irritative reactions were evaluated according to the intensity of blue eruption formation and cauterization. The following conclutions were obtained. 1. The skin irritative reaction to FG was more potent than that to liquefied phenol and as potent as that to FC. 2. The skin irritative reaction to guaiacol was remarkably less potent than that to liquefied phenol and slightly milder than that to cresol. 3. The minimum causative concentration of FG was the same with that of FC, and that of guaiacol was the same with that of cresol.
1983-12-25