歯内療法に用いられる精油類の局所刺激性

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Little work has been done to study the inflammatory potential of essential oils which are used frequently as endodontic medicaments. In this report three essential oils (clove oil, eucalyptus oil, peppermint oil) and methyl salicylate which is the main constituent of winter green oil were compared on their inflammatory potency with use of liquefied phenol (JP) as a positive control and normal saline solution as a negative control, and the minimal inflammatory dose of each was evaluated. The samples were diluted with olive oil by multiple method prior to the test. The paper disc soaked with 30μl of sample solution was stuck on the shaved dorsal skin with an adhesive tape for 30 minutes of male rabbits of New Zealand White strain and then the die solution, 1% Evan's blue, was injected intravenously. The inflammatory potency was evaluated according to the intensity of blue eruption formation and cauterization. The results obtained were as follows : 1. The inflammatory effect of clove oil was the severest of those of four samples, but it was remarkably milder than that of liquefied phenol. 2. The inflammatory effect of eucalyptus oil was severer than that of methyl salicylate, which was slightly severer than that of peppermint oil. 3. The ratio of the area of blue eruption to liquefied phenol was 0.39 for clove oil, 0.34 for eucalyptus oil, 0.25 for methyl salicylate and 0.22 for peppermint oil. There was no significant difference (p<0.05) in the area of blue eruption between methyl salicylate and peppermint oil. 4. Concerning blue eruption formation, the minimal inflammatory dose of clove oil was the same with that of methyl salicylate, and that of eucalyptus oil was the same with that of peppermint oil. 5. The cauterization was caused only by the contact with clove oil.
九州歯科学会の論文
1986-04-25

歯内療法に用いられる精油類の局所刺激性

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