3 種フェノールカンフル製剤の局所刺激性

概要

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The primary irritations by three phenol camphor preparations, Chlumsky's solution, dental phenol with camphor (JP) and Murakami Camphenic, and by liquefied phenol (JP) were observed with a preparation applied on the shaved dorsal skin of male rabbits. The skin reactions were evaluated according to the intensity of erythema and edema formation, and cauterization. Differences were scarcely recognized among the reactions to three phenol camphor preparations. A dye, 1% Evan's blue was injected intravenously in the dose of 6 ml/kg. Blue eruption formation caused by exudation of dye was observed at the application spot. The time required for the appearance of blue eruption and its size were measured. The following conclusions were obtained : 1. The irritative reactions to the three phenol camphor preparations were remarkably milder than those to liquefied phenol (JP). 2. In comparsion of the three phenol camphor preparations, difference between dental phenol with camphor (JP) and Chlumsky's solution was not found, while Murakami Camphenic showed a slightly severer irritation.
九州歯科学会の論文
1980-01-25