ラットに及ぼす塩化ジフェニールの影響

概要

論文の詳細を見る
Because of the fact that chlorinated diphenyl compounds were originally developed as heat-exchanging medium for exclusive use in some processes of chemical industry, it is no wonder that there lacks any information with regard to its biological effect, much less with regard to human toxicity. The present study was undertaken to examine the possible toxic effect of one of such compounds marketed under the name of Kanechlor when it was administered to rats orally for 10 to 20 days period in doses ranging from 2, 500 ppm to 10, 000 ppm in 0.5 ml of solution per day. The results were summarized as follows. 1. The drug did not cause any one case of death among the total of 102 animals tested. 2. The animals failed to gain weight and showed poor appearance of hair and dullness of mobility. 3. The sucklings from mother rats given to compound likewise showed similar morbid symptoms reflecting contamination of breast milk with the compound.
九州歯科学会の論文
1970-05-31