ビタミンB_1の拮抗物質にかんする研究 : (IX)ビタミンB_1に関連するピリミジン化合物のビタミンB_1要求性乳酸菌ならびに酵母にたいする増殖抑制(2) ピリミジン化合物による増殖阻害の特異性

概要

論文の詳細を見る
The growth inhibitory effects of 2-methyl-4-amino-5-aminomethylpyrimidine (AMPm) and some pyrimidine compounds for thiamine requiring L.fermenti and Kl. apiculata decreased with increasing amount of thiamine and were almost compensated by the presence of 1/2500 and 1/25000 equimolecular amounts of thiamine, respectively and no effects were seen for such microorganisms requiring no thiamine, as L.arabinosus 17-5,L.casei, Streptococcus faecalis and Sacch. carlsbergensis. From these results, the inhibitory effect of the pyrimidine compounds seems to be specifically antagonistic with thiamine. As shown in Fig.1 and 2,for the growth of L.fermenti AMPm inhibited the utilization of thiamine diphosphate (TDP) 3 to 6 times more than that of thiamine, while for Kl.apiculata no difference of inhibitory effect of AMPm was observed between thiamine and TDP.
日本ビタミン学会の論文
1964-11-25