ビタミンB_1の溶存酸素による酸化 : (I)いわゆる耐熱性因子によるビタミンB_1の分解と溶存酸素の影響

概要

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Thiamine is unstable in its dilute solution with so-called thermostable factors such as rutin, hydroquinone etc. PABA also accelerates the oxidation of thiamine in its neutral or alkaline solution by dissolved oxygen but the exclusion of oxygen by saturation with N_2 or addition of alkaline ammonium ferrous sulfate and sodium tartrate prevents the oxidation. The PABA solution, irradiated by ultraviolet ray, was more effective to oxidize thiamine than the non-irradiated one, but its oxidation was greatly diminished by expelling dissolved oxygen by the same procedure. Dissolved oxygen carries out the oxidation of thiamine into thiamine disulfide in its alkaline solution of pH 9.5 most effectively, and the thermostable factors enable this oxidation even in less alkaline media. If dissolved oxygen is expelled, thiamine is stable in the alkaline medium even at the presence of thermostable factors. This evidence was presented by using rutin, hydroquinone, and extract from azelea leaves, thus thermostable factors destroying thiamine were proved as accelerators for the oxidation of thiamine by dissolved oxygen.
日本ビタミン学会の論文