ビタミンB_1関連化合物の代謝 : (I)THIOTHIAMINE類似化合物の代謝 : (1)DESOXYMETHYLTHIOTHIAMINEの代謝

概要

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Among several compounds analogous to thiothiamine, 3-[2'-methyl-4'-aminopyrimidyl-(5')]-methyl-4,5-dimethylthiothiazolone-(2)(I) and 2-ethyl-thiothiamine (II) were proved to be estimated by benzoyl peroxide-NaOH method just as applied to thiothiamine. The intensity of fluorescence of thiochrome-analogous compounds is both weaker than that of thiochrome. (I) and (II) were given to rats by injection or per os, the amounts excreted into 24 hour-urine were estimated. (II) showed the same pattern as thiothiamine did, whereas (I) was excreted into urine at the far less amount than thiothiamine. Only less than 10% of the given (I) (4.55mg of its HCl salt) was recovered from 24 hour-urine either by injection or per os. Thus (I) was quickly transformed into its metabolite, probably a thiochrome-like fluorescent compound which will be described later.
日本ビタミン学会の論文