熱殺菌に関する研究 : (第6報) 熱殺菌による醗酵培地の変質ならびに最適熱殺菌条件の決定法について

概要

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The effect of medium sterilization with heat on the yield of some fermentation products…Bacillus subtilis cells, a proteolytic enzyme produced by Bacillus subtilis and cells of Saccharomyces cerevisiae…was examined. Contaminants in the media studied were assumed to be the spores of Bacillus stearothermophilus ATCC 10149,operating conditions (time and temperature) of medium sterilization which resulted in the most favorable fermentation was calculated using the life-span distribution theory, reported previously.It was found that the sterilization temperature must be as high as possible for the growth of Sacch. cerevisiae. However, for the growth and enzyme production of Bac. subtilis the operating conditions which were most advisable depended appreciably on the value of kθ which was a function of the number of contaminants and the degree of sterilization required.The practice of the high temperature and short time, which has usually been recommended for mdium sterilization, should be re-assessed from case to case.
社団法人日本生物工学会の論文
1967-08-25