慢性腎炎病態モデルラットにおける25-Hydroxycholecalciferol及び1α-Hydroxycholecalciferolの代謝の比較

概要

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When injected i. v., ^3H-25-OH-D_3 was significantly excreted into the urine in the experimental nephritic rat of Shibata et al. (30〜40% radioactivity), while in control rat this was 1〜2%. Excretion of ^3H-1α-OH-D_3 was not much in the nephritic rat (1〜10%) than in the control rat (1〜2%). There were good linear relationship between the amount of protein and total radioactivity in 24 hour urine of the nephritic rat injected i. v. ^3H-1α-OH-D_3 or ^3H-25-OH-D_3. In the nephritic rat, metabolism of 25-OH-D_3 to 24,25-(OH)_2-D_3 was significantly injured while metabolism of 1α-OH-D_3 to 1α, 25-(OH)_2-D_3 was almost the same as that of the control rat. It can be assumed that the enhanced excretion of ^3H-25-OH-D_3 in the nephritic rat was due to the increase in excretion of 25-OH-D_3 binding plasma protein, α-globulin, while little lipoprotein which may bind 1α-OH-D_3 was excreted.
日本ビタミン学会の論文
1978-10-25