The Dual Functions of Biphenyl-degrading Ability of Pseudomonas sp. KKS102 : Energy Acquisition and Substrate Detoxification(Food & Nutrition Science)

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概要

• 論文の詳細を見る

• The bph operon of Pseudomonas sp. KKS102 is constituted of 11 bph genes which encode enzymes for biphenyl assimilation. Growth of a mutant in which a large part of the bph operon was deleted was inhibited by biphenyl in a concentration-dependent manner. We constructed a series of bph operon deletion mutants and tested for their biphenyl sensitivity. Growth inhibition by biphenyl was more prominent with the mutants defective in bphA1, bphB, bphC, and bphD, which were clustered in the bph operon and working in the early stage of the biphenyl degradation. The mutant defective in bphE, which was working at the late stage and forming a different cluster from the early stage genes, was not much inhibited by biphenyl. These indicate that biphenyl is detoxified by enzymes which function in the early stage of biphenyl assimilation and thus detoxification of substrates as well as energy acquisition could have played an important role in the evolution of the KKS102 bph operon.

• 社団法人日本農芸化学会の論文
• 2003-09-23

著者

• Ohta Akinori

  Department Of Agricultural Chemistry The University Of Tokyo

• Ohtsubo Yoshiyuki

  Department Of Life Sciences Graduate School Of Life Sciences Tohoku University

• Ohtsubo Yoshiyuki

  Department Of Biotechnology The University Of Tokyo

• Ohta Akinori

  Dep. Of Biotechnology The Univ. Of Tokyo

• DELAWARY Mina

  Department of Biotechnology, University of Tokyo

• Delawary Mina

  Department Of Biotechnology University Of Tokyo:department Of Oncology Institute Of Medical Science

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