Large-Scale Preparation of (+)-Disparlure, the Gypsy Moth Pheromone, by a Practical Chemico-Enzymatic Procedure
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概要
- 論文の詳細を見る
The sharpless asymmetric epoxidation of 8-methyl-2-nonen-1-ol performed on a large scale (over 5 moles) at room temperature gave (2S, 3R)-2,3-epoxy-8-methyl-1-nonanol with 52%ee. The produced epoxy alcohol of low optical purity was subjected to lipase-catalyzed enatioselective acylation in order to increase the optical purity up to 85%ee. Recrystalyzation of the corresponding 3,5-dinitrobenzoate gave optically pure epoxy alcohol. (+)-Disparlure, the gypsy moth pheromone, was synthesized in two steps from the thus obtained optically pure epoxy alcohol.
- 社団法人日本生物工学会の論文
- 1992-04-25
著者
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FUKUSAKI EI-ICHIRO
Department of Biotechnology, Graduate School of Engineering, Osaka University
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Fukusaki Eiichiro
Department Of Biotechnology Graduate School Of Engineering Osaka University
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OMATA TETSUO
Product Development Center, Medical Products Sector, Nitto Denko Co.
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SATODA SHIRO
Medical Research Center, Nitto Denko Corporation
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YUASA HIROYUKI
Medical Research Center, Nitto Denko Corporation
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SENDA SHUJI
Medical Research Center, Nitto Denko Corporation
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OMATA TETSUO
Medical Research Center, Nitto Denko Corporation
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FUKUSAKI Eiichiro
Medical Research Center, Nitto Denko Corporation
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NAKAZONO Yutaka
Medical and Membrane Research Laboratory, Nitto Denko Co.
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Senda S
Medical Research Center Nitto Denko Corporation
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Omata Tetsuo
Product Development Center Medical Products Sector Nitto Denko Co.
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Yuasa Hiroyuki
Medical Research Center Nitto Denko Corporation
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Senda Shuji
Medical Product Division Product Development Center Nitto Denko
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Nakazono Yutaka
Medical And Membrane Research Laboratory Nitto Denko Co.
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