Lipase-Catalyzed Kinetic Resolution of 2,3-Epoxy-8-Methyl-1-Nonanol, the Key Intermediate in the Synthesis of the Gypsy Moth Pheromone
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概要
- 論文の詳細を見る
Lipase-catalyzed enantioselective acylation of (±)-2,3-epoxy-8-methyl-1-nonanol with acetic anhydride in diisopropyl ether yielded (2S, 3R)-1-acetoxy-2,3-epoxy-8-methylnonane with 79% enantiomeric excess (ee). The optical purity of the epoxy ester was improved up to 95%ee by a second step of lipase-catalyzed enantioselective alcoholysis in diisopropyl ether.
- 社団法人日本生物工学会の論文
- 1992-04-25
著者
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FUKUSAKI EI-ICHIRO
Department of Biotechnology, Graduate School of Engineering, Osaka University
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Fukusaki Eiichiro
Department Of Biotechnology Graduate School Of Engineering Osaka University
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OMATA TETSUO
Product Development Center, Medical Products Sector, Nitto Denko Co.
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SATODA SHIRO
Medical Research Center, Nitto Denko Corporation
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YUASA HIROYUKI
Medical Research Center, Nitto Denko Corporation
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SENDA SHUJI
Medical Research Center, Nitto Denko Corporation
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OMATA TETSUO
Medical Research Center, Nitto Denko Corporation
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FUKUSAKI Eiichiro
Medical Research Center, Nitto Denko Corporation
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NAKAZONO Yutaka
Medical and Membrane Research Laboratory, Nitto Denko Co.
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Senda S
Medical Research Center Nitto Denko Corporation
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Omata Tetsuo
Product Development Center Medical Products Sector Nitto Denko Co.
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Yuasa Hiroyuki
Medical Research Center Nitto Denko Corporation
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Senda Shuji
Medical Product Division Product Development Center Nitto Denko
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Nakazono Yutaka
Medical And Membrane Research Laboratory Nitto Denko Co.
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