Apolipoprotein A-1 of Japanese Quail: cDNA Sequence and Modulation of Tissue Expression by Cholesterol Feeding

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概要

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• Apolipoprotein (apo) A-1 cDNA was amplified by the reverse-transcriptase-polymerase chain reaction (RT-PCR). Primers were synthesized according to the nucleotide sequence of chicken apo A-1, and the identity of apo A-1 cDNA was confirmed by comparing with the N-terminal amino acid sequence. The open reading frame of apo A-1 cDNA consists of 795 nucleotides, and it is capable of coding a polypeptide of 264 amino acids. A comparison between quail and chicken apo A-1 revealed 94.5% homology in the nucleotide sequence and 91.7% homology in the amino acid sequence. There was a similar 11- or 22-amino acid repeat in quail apo A-1 as was the case for chicken apo A-1. Apo A-1 mRNA was evaluated to be 1.4 k in length and was expressed in various tissues of Japanese quail: the liver, small intestine, lung, kidney, heart, and muscle. A quantitative evaluation, however, revealed that the liver and small intestine were the major organs for apo A-1 synthesis, accounting for more than 90% of the total expression of apo A-1 mRNA. Besides apo A-1 mRNA (1.4k in length), a transcript of 4.1 k was detected in all the tissues examined, with a magnitude ranging from 5 to 10% of the apo A-1 mRNA level. The effect of cholesterol level on the expression of apo A-l mRNA was studied to address the physiological significance of apo A-1 in the liver, small intestine, and muscle. The level of cholesterol in the liver and breast muscle was increased by feeding with cholesterol and reached a saturation level at day 7. There was also a temporal rise of cholesterol level at day 7 in the small intestine. Dietary cholesterol increased the expression of apo A-1 mRNA two fold in both the liver and small intestine. This was not the case for breast muscle, in which the expression of apo A-1 mRNA was not modulated by the cholesterol level.

• 社団法人日本農芸化学会の論文
• 1997-02-23

著者

• Toda Takayoshi

  中部徳洲会病院 臨床病理

• Toda Takayoshi

  鹿児島大学 連合農学研究科

• OKU Hirosuke

  Laboratories of Applied Biochemistry, University of The Ryukyus

• CHINEN Isao

  Laboratories of Applied Biochemistry

• Oku Hirosuke

  Center Of Molecular Biosciences Tropical Biosphere Res. Center Univ. Of The Ryukyus

• TODA Takayoshi

  Department of Clinical Laboratory Medicine, School of Medicine, University of the Ryukyus Hospital

• NAGATA Junichi

  Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus

• ISHIKAWA Makoto

  Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus

• NEYAZAKI Kimihiko

  Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus

• SHINJYO Choyu

  Laboratory of Plant and Animal Breeding, Faculty of Agriculture, University of The Ryukyus

• Chinen Isao

  Laboratories Of Applied Biochemistry University Of The Ryukyus

• Chinen I

  Univ. The Ryukyus Okinawa Jpn

• Chinen Isao

  Laboratory Of Applied Biochemistry Faculty Of Agriculture University Of The Ryukyus

• Chinen Isao

  Laboratories Of Applied Biochemistry Faculty Of Agriculture University Of The Ryukyus

• Nagata Junichi

  Kyushu International University

• Nagata J

  Laboratory Of Applied Biochemistry Faculty Of Agriculture University Of The Ryukyus

• Nagata J

  Univ. Ryukyus Okinawa Jpn

• NAGATA Junichi

  Devision of Materials Science, Faculty of Integrated Arts and Sciences Hiroshima University

• Ishikawa M

  T. Hasegawa Co. Ltd. Kawasaki Jpn

• Oku Hirosuke

  Laboratories Of Applied Biochemistry University Of The Ryukyus

• Shinjyo C

  Laboratory Of Plant And Animal Breeding Faculty Of Agriculture University Of The Ryukyus

• Toda Takayoshi

  Department Of Clinical Laboratory Medicine And Research Institute Of Comprehensive Medicine School O

• Oku H

  Division Of Molecular Biotechnology Center Of Molecular Bioscience University Of The Ryukyus

• Oku Hirosuke

  Division Of Molecular Biotechnology Center Of Molecular Biosciences University Of The Ryukyus

• Oku Hirosuke

  Laboratory Of Applied Biochemistry Faculty Of Agriculture University Of The Ryukyus

• Neyazaki Kimihiko

  Laboratory Of Applied Biochemistry Faculty Of Agriculture University Of The Ryukyus

• NAGATA Junichi

  Laboratory of Applied Biochemistry, Faculty fo Agriculture, and Clinical Laboratory Department, University of the Ryukyus

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