Effect of Branched-Chain Fatty Acids on Fatty Acid Biosynthesis of Human Breast Cancer Cells

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概要

• 論文の詳細を見る

• This paper describes the antitumoral activity of branched-chain fatty acid (BCFA) in human breast cancer cells with an emphasis on its effect on fatty acid biosynthesis. First, the relationship between chain-length and antitumoral activity was studied. The highest activity was observed with iso-16 : 0, and the activity decreased with increase or decrease of the chain-lengths from C16 : 0. Anteiso-BCFA, as well as iso-series, was cytotoxic to the breast cancer cells. Cytotoxicity of BCFA was comparable to that of conjugated linoleic acid known as antitumoral fatty acid. Incubation of breast cancer cells with BCFA (13-methyltetradecanoic acid) significantly reduced the [^<14>C] acetate incorporation into free fatty acid and fatty acid esters, showing the inhibition of fatty acid biosynthesis by BCFA. Examination of substrate level effect found that BCFA slightly inhibited fatty acid synthetase and acetyl-CoA carboxylase, and significantly the glucose-6-phosphate dehydrogenase which was the main NADPH generating system in breast cancer cells. The present study thus suggests that BCFA synthetically lowers the fatty acid biosynthesis by reducing the precursors, in addition to its direct inhibitory effect on fatty acid synthetase.

• 日本ビタミン学会の論文

著者

• IWASAKI Hironori

  Center for Nuclear Study, University of Tokyo

• Toda Takayoshi

  中部徳洲会病院 臨床病理

• Toda Takayoshi

  鹿児島大学 連合農学研究科

• Oku Hirosuke

  Center Of Molecular Biosciences Tropical Biosphere Res. Center Univ. Of The Ryukyus

• IWASAKI Hirononi

  Center of Nuclear Study (ONS), University of Tokyo

• Iwasaki Hirononi

  Center For Nuclear Study (cns) University Of Tokyo

• OKU HIROSUKE

  Division of Molecular Biotechnology, Center of Molecular Bioscience, University of the Ryukyus

• IWASAKI HIRONORI

  Division of Molecular Biotechnology, Center of Molecular Bioscience, University of the Ryukyus

• TODA Takayoshi

  Department of Clinical Laboratory Medicine, School of Medicine, University of the Ryukyus Hospital

• WONGTANGTINTHARN Sawitree

  United Graduate School of Agricultural Sciences, Kagoshima University

• 岩崎 公典

  Div. Of Molecular Biotechnology Center Of Molecular Bioscience Univ. Of The Ryukyus

• Oku Hirosuke

  Division Of Molecular Biotechnology Center Of Molecular Bioscience University Of The Ryukyus

• Toda Takayoshi

  Department Of Clinical Laboratory Medicine And Research Institute Of Comprehensive Medicine School O

• Oku H

  Division Of Molecular Biotechnology Center Of Molecular Bioscience University Of The Ryukyus

• Oku Hirosuke

  Division Of Molecular Biotechnology Center Of Molecular Biosciences University Of The Ryukyus

• Oku Hirosuke

  Division Of Molecular Biotechnology And Center For Molecular Bioscience University Of The Ryukyus

• Iwasaki Hironori

  Division Of Molecular Biotechnology And Center For Molecular Bioscience University Of The Ryukyus

• Oku Hirosuke

  Laboratory Of Applied Biochemistry Faculty Of Agriculture University Of The Ryukyus

• Wongtangtintharn Sawitree

  United Graduate School Of Agricultural Sciences Kagoshima University

• IWASAKI Hironori

  Center for Nuclear Study (CNS), University of Tokyo

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