Morphological and Biochemical Evaluation of the Induction of Atherosclerosis in Japanese Quails
スポンサーリンク
概要
- 論文の詳細を見る
A total of 77 birds were divided into 7 groups which were fed the following diets : Group I, basal ; Group II, 5% corn oil (CO) + 0.5% cholesterol (CH) ; Group III, 5% CO + 2% CH; Group IV, 5% CO + 4% CH; Group V, 15% CO + 0.5% CH ; Group V I, 15% CO + 2% CH; Group VII, 15% CO + 4% CH. Significant increase of serum lipid, accumulation of lipid in the liver, and lipid-rich aortic lesions were produced in Groups IV, VI and VIII. However, hyperlipidemia correlated well with the extent of hepatic lipid accumulation and severity of aortic atherosclerosis in Group VI. Proliferating intimal cells showed positive reaction to antibodies for vimentin and alpha-1-antichymotrypsin implicating an important role of phenotypical transformation of intimal cells from the medial fibroblastic cells in the development of aortic atherosclerosis. These results suggest that Japanese quail is highly susceptible to atherosclerosis, and the optimal dietary level of cholesterol and corn oil is 2% and 15%, respectively to induce lipid-rich aortic lesions in Japanese quail.
- 1990-12-14
著者
関連論文
- Isoprenoids of Okinawan Mangroves as Lipid Input into Estuarine Ecosystem
- Effect of Kokuto, a Non-Centrifugal Cane Sugar, on the Development of Experimental Atherosclerosis in Japanese Quail and Apolipoprotein E Deficient Mice
- Analysis of Microsatellite Instability and Loss of Heterozygosity in Human Aortic Atherosclerotic Lesions
- Effect of Branched-Chain Fatty Acids on Fatty Acid Biosynthesis of Human Breast Cancer Cells
- Conjugated Linoleic Acid (CLA) Inhibits Fatty Acid Synthetase Activity in Vitro(Food & Nutrition Science)
- Increased Cholesterol Absorption by Hyperlipidemia Atherosclerosis Prone (LAP) Japanese Quail
- Apolipoprotein A-I of Hyperlipidemia Atherosclerosis Prone (LAP) Quail : cDNA Sequence and Tissue Expression
- NADH-Dependent Inhibition of Branched-Chain Fatty Acid Synthesis in Bacillus subtilis
- Apolipoprotein A-1 of Japanese Quail: cDNA Sequence and Modulation of Tissue Expression by Cholesterol Feeding
- Selective Use of L-Valine and L-Isoleucine for the Biosynthesis of Branched-chain Fatty Acids in Rat Skin
- Chain Structure and Composition of Fatty Alcohol in the Monoester Fraction of Rat Skin Surface Lipid
- Morphological and Biochemical Evaluation of the Induction of Atherosclerosis in Japanese Quails
- Efficient Preparation of Liposomes Encapsulating Food Materials Using Lecithins by a Mechanochemical Method
- Comparative Study of the Effect of Basal Diet Formulation, Dietary Fat and Cholesterol Levels on the Development of Aortic Atherosclerotic Lesions in B6.KOR-Apoeshl Mice
- Effect of Peucedanum japonicum Thunb on the Expression of Obesity-Related Genes in Mice on a High-Fat Diet
- Lipoprotein and Apoprotein Profiles of Hyperlipidemic Atherosclerosis-Prone Japanese Quail
- Effect of Dietary Cholesterol on the Activities of Key Enzymes of Cholesterol Metabolism in Hyperlipidemia- and Atherosclerosis-Prone Japanese Quail
- Effect of Peucedanum japonicum Thunb Extract on High-fat Diet-induced Obesity and Gene Expression in Mice
- Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L.