Apolipoprotein A-I of Hyperlipidemia Atherosclerosis Prone (LAP) Quail : cDNA Sequence and Tissue Expression

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概要

• 論文の詳細を見る

• Apolipoprotein A-I (apo A-I) has an important role in the transport of cholesterol. This study describes the complete nucleotide and deduced amino acid sequence for apo A-I of LAP quail. A full length apo A-I cDNA clone for hyperlipidemia atherosclerosis prone (LAP) quail was isolated from a λgt10 liver cDNA library. The DNA sequence of LAP apo A-I cDNA was similar to that of normal Japanese quail. The deduced amino acid sequence of LAP apo A-I was hence identical to that of normal Japanese quail. LAP apo A-I mRNA is about 1.4 kilobases in length and expressed in a variety of tissues including small intestine, liver, lung, breast muscle, testis, and heart. Although the tissue distribution of apo A-I was similar between strains, LAP quail expressed more apo A-I mRNA than normal Japanese quail in all tissues examined. This tendency was pronounced with the small intestine. Although the concentration of serum apo A-I did not correlate with the tissue expression of mRNA, the observation may suggest that the increased apo A-I expression in LAP strain had some relevance to the susceptibility of this strain to the experimental atherosclerosis.

• 社団法人日本農芸化学会の論文
• 1999-01-23

著者

• Toda Takayoshi

  中部徳洲会病院 臨床病理

• Toda Takayoshi

  鹿児島大学 連合農学研究科

• OKU Hirosuke

  Laboratories of Applied Biochemistry, University of The Ryukyus

• CHINEN Isao

  Laboratories of Applied Biochemistry

• Oku Hirosuke

  Center Of Molecular Biosciences Tropical Biosphere Res. Center Univ. Of The Ryukyus

• Oda Koji

  Division Of Surgical Oncology Department Of Surgery Nagoya University Graduate School Of Medicine

• IWASAKI HIRONORI

  Division of Molecular Biotechnology, Center of Molecular Bioscience, University of the Ryukyus

• TODA Takayoshi

  Department of Clinical Laboratory Medicine, School of Medicine, University of the Ryukyus Hospital

• IWASAKI Hironori

  Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus

• NASU Tetsuo

  Department of Beterinary Anatomy, Faculty of Agriculture, Miyazaki University

• MIYAGI Tsuyoshi

  Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus

• ODA Koji

  Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus

• Chinen Isao

  Laboratories Of Applied Biochemistry University Of The Ryukyus

• Chinen I

  Univ. The Ryukyus Okinawa Jpn

• Chinen Isao

  Laboratory Of Applied Biochemistry Faculty Of Agriculture University Of The Ryukyus

• Chinen Isao

  Laboratories Of Applied Biochemistry Faculty Of Agriculture University Of The Ryukyus

• 那須 哲夫

  宮崎大学農学部獣医学科

• Iwasaki Hironori

  Division Of Molecular Biotechnology Center Of Molecular Bioscience University Of The Ryukyus

• ODA Koji

  Telecom Engineering Center

• Oda Koji

  First Department Of Surgery Nagoya University School Of Medicine

• Oda Koji

  Laboratory Of Applied Biochemistry Faculty Of Agriculture University Of The Ryukyus

• Nasu Tetsuo

  Department Of Beterinary Anatomy Faculty Of Agriculture Miyazaki University

• Nasu Tetsuo

  Department Of Veterinary Anatomy Faculty Of Agriculture Miyazaki University

• Oku Hirosuke

  Division Of Molecular Biotechnology Center Of Molecular Bioscience University Of The Ryukyus

• Oku Hirosuke

  Laboratories Of Applied Biochemistry University Of The Ryukyus

• Toda Takayoshi

  Department Of Clinical Laboratory Medicine And Research Institute Of Comprehensive Medicine School O

• MIYAGI TSUYOSHI

  Zuisen Distillers Co. Ltd.

• Nasu T

  Yamaguchi Univ. Yamaguchi Jpn

• Oku H

  Division Of Molecular Biotechnology Center Of Molecular Bioscience University Of The Ryukyus

• Oku Hirosuke

  Division Of Molecular Biotechnology Center Of Molecular Biosciences University Of The Ryukyus

• Oku Hirosuke

  Laboratory Of Applied Biochemistry Faculty Of Agriculture University Of The Ryukyus

• Okada Kosuke

  Department Of Gastroenterology Graduate School Of Comprehensive Human Sciences University Of Tsukuba

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