Oral Passive Immunization Effect of Anti-Human Rotavirus IgY and Its Behavior against Proteolytic Enzymes
スポンサーリンク
概要
- 論文の詳細を見る
The neutralization titer of anti-human rotavirus (HRV) IgY was completely inactivated by pepsin at pH 2.0. However, it was not significantly affected by trypsin or chymotrypsin under certain conditions. The immunological activity of the IgY was observed in the intestine of suckling mice for 2h after oral administration and the activity rapidly decreased thereafter. The effects of oral supply of IgY were thus estimated for HRV-induced diarrhea in suckling mice and it was found that a previous supply of the IgY (1h before HRV infection) completely prevented the HRV-induced diarrhea. The preventive effect was decreased as the time gap between IgY administration and HRV infection was longer. However, the oral supply of the IgY within 24h after HRV infection was still effective and decreased the incidence of HRV diarrhea in suckling mice.
- 社団法人日本農芸化学会の論文
- 1993-07-23
著者
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赤地 重宏
三重県科学技術振興センター 保健環境研究部
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Kim M
Tokyo Univ. Agriculture Tokyo Jpn
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Kim M
Central Research Laboratories Taiyo Kagaku Co. Ltd.
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Kim Mujo
Central Research Laboratories Taiyo Kagaku Co. Ltd.
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Kim Mujo
Central Research Laboratories Of Taiyo Kagaku Co. Ltd.
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YAMAMOTO Takehiko
Department of Biotechnology, Fukuyama University
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Yamamoto T
Novelty Materials Research Institute Hannan R&d Center Fuji Oil Co.ltd.
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Hatta Hajime
Central Research Laboratories, Taiyo Kagaku Co., Ltd.
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Tsuda Ken
Central Research Laboratories, Taiyo Kagaku Co., Ltd.
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EBINA Takusaburo
Division of Immunology, Research Institute Miyagi Cancer Center
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Hatta H
Kyoto Women's Univ. Kyoto Jpn
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Hatta Hajime
Central Research Laboratories Taiyo Kagaku Co. Ltd.
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Yamamoto Takehiko
Department Of Biology Faculty Of Science Osaka City University
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Akachi Shigemitsu
Central Research Laboratories, Taiyo Kagaku Co., Ltd.
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Tsuda K
Central Research Laboratories Taiyo Kagaku Co. Ltd.
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EBINA Takusaburo
Sendai Institute of Microbiology
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Akachi Sigemitu
Central Research Laboratories Taiyo Kagaku Co. Ltd.
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Ebina Takusaburo
Division of Immunology, Miyagi Cancer Center Research Institute
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