4.肝疾患時の補体に関する研究 (続報)(第3回補体シンポジウム II 各種疾患における補体及び補体成分の変動)

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This work was undertaken to examine the clinical significance of raised complement level in infectious hepatitis. Total C' was performed according to Mayer's 50% hemolytic method and also the method of Pillemer et al was used in the determination of total C' and C' components. Serum properdin level was determined according to Pillmeer et al and serum lysozyme was also determined by Frankel-Conrat's or Tolles Fromagel's method with the modification by Eizai institute, Japan. The results were as follows: 1) In the icteric phase of acute hepatitis (A.H.)(33 cases) total C' level slightly raised (Mean value: 42.0 units/ml), in the subicteric phase A.H. sera (22 cases) showed relatively high titers of total C' (46.4 units/ml) and in the reconvalescent stage A.H. sera with slightly high S-GPT level showed slightly high titers of total C' (39.7 units/ml) and A.H. sera became normal when the patients recovered. In acute hepatitis the activities of S-GPT and alkaline-phosphatase and pathological Bromsulphalein retention rate became normal when total C' level returned to normal level. 2) In the acute phase of acute hepatitis raised S-GPT activity was coincident with (or just a little later) raised total C' level. 3) In 5-8 weeks after the onset of acute hepatitis some sera showed slightry raised level in total C', and some of these cases led to the development into chronic hepatitis. 4) In primary biliary cirrhosis or intrahepatic cholestasis pathological sera showed raised total C' level with hyperbilirubinemia, hypercholesterinemia and high serum alkaline phosphatase activity. 5) Cirrhosis sera with hypersplenismus usually showed lowered serum total C', but these sera showed slightly high titers after splenectomy. 6) The above clinical experiments in contrast to the other diseases with high serum C' level indicated that the mechanism of raised serum C' was dependent upon various kind of factors. 7) It seems that acute hepatitis serum properdin and lysozyme levels were not correlated with serum total C' level.
日本アレルギー学会の論文
1966-11-30

4.肝疾患時の補体に関する研究 (続報)(第3回補体シンポジウム II 各種疾患における補体及び補体成分の変動)

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