肝疾患における異常塩基性γグロブリン

概要

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The serum proteins abnormaly migrated to the negative zone in comparison with normal sera were observed in electrophoresis. We studied these abnormaly basic proteins. 1) In 152 of 8400 subjects the serum proteins were significantly migrated to the negative zone in electrophoresis. 2) According to immunoelectrophoresis of the serum proteins these abnormaly basic proteins were IgG. These proteins were absorbed by Protein A, and so we supposed subclass of these proteins was not IgG3. 3) Investigation on neuraminidase treatment revealed that these abnormaly basic proteins were not formed by release of sialic acid from carbohydrate units of IgG. 4) Many patients with these proteins had liver diseases (37 of 59 patients, 62.7%). And many of these patients with liver diseases had HBsAg (29 of 37 patients, 78.4%). 5) In some cases with chronic hepatitis these proteins were found to increase and decrease in parallel with disease activity.
社団法人日本肝臓学会の論文