転移性脊髄硬膜外腫瘍による脊髄循環障害 : 脊髄局所血流量および炭酸ガス反応性の障害と病態との相関

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An experimental model of the spinal epidural neoplasm was produced in rats by injecting Walker 256 carcinoma cell suspension anterior to the T-12/13 vertebral body. Using this animal model, regional spinal cord blood flow (rSCBF) and its response to CO_2 inhalation (CO_2-R) were estimated by ^<14>C-antipyrine autoradiography and the hydrogen clearance method. In the early stage of weakness of the hind limbs, axonal swelling and edema of the white matter were revealed by histopathological examination, while both rSCBF and CO_2-R remained normal. In the middle stage of weakness, the tumor invaded the spinal canal and compressed the spinal cord epidurally, and edema of white matter progressed although the gray matter was scarcely affected. The rSCBF decreased gradually at the compressed and caudal levels. Disturbance of CO_2-R was also noted at the compressed and caudal levels, and appeared to preceed the rSCBF decrease. The disturbances of rSCBF and CO_2-R were remarkable at the compressed level than at the caudal level. No disturbances were observed at the rostral level. In the end stage of weakness, disturbances of rSCBF and CO_2-R progressed rapidly and microangiography revealed obstruction of the vertebral venous plexus at the level of compression, while the greater vessels (radicular arteries, anterior spinal artery, posterior spinal arteries and posterior median vein) were patent even in this stage. From the data collected, the pathophysiology in the spinal epidural neoplasm is considered as follows: 1) the vertebral venous plexus is stenosed or obstructed by the epidural tumor in the early stage of weakness and vasogenic edema starts in the spinal cord; 2) as the tumor grows, mechanical compression of the spinal cord occurs in addition to obstruction of the vertebral venous plexus, and the edema progresses further; and 3) rSCBF decreases rapidly to the critical flow level in the end stage and the cord function becomes irreversible.
日本脳神経外科学会の論文
1981-12-15

転移性脊髄硬膜外腫瘍による脊髄循環障害 : 脊髄局所血流量および炭酸ガス反応性の障害と病態との相関

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