下垂体腺腫例の内分泌学的検索 : 治療前より治療後長期follow upにおける下垂体機能障害の変遷について

概要

論文の詳細を見る
Forty-two cases of large pituitary adenomas (including 19 non-functioning adenoma cases, 8 PRL-secreting adenoma cases and 15 GH-secreting adenoma cases) were examined for pituitary insufficiency prior to treatment by operation and/or irradiation and more than 2 years thereafter. PRL-secreting cases exhibited the highest degree of pre-treatment pituitary insufficiency, while non-functioning adenomas a medium degree, and GH-secreting adenomas a minor degree. These were in proportion to the dimensions of tumors. The incidence of disturbance in secretion of hormones were 100% in GH, about 50% in LH and TSH, and a mere 20% in ACTH, FSH and PRL. In GH secreting adenomas, however, TSH secretion was disturbed in about 70%. A 2-year follow-up study after treatment revealed increased disturbances in LH, FSH and PRL compared to those before treatment, though no remarkable change was observed in ACTH and TSH. Irradiations were responsible for aggravation of disturbances and its influence was most dramatic in LH, FSH and PRL. PRL levels in PRL-secreting cases decreased gradually for 2 years after treatment at rates of 19 to 49% (25.5% average) of the pre-treatment levels. In 2 of these cases, PRL levels showed a 10% decrease of the pre-treatment levels 4 years after treatment. In 3 out of 7 GH-secreting cases, which did not respond to surgery in terms of decrease in levels of GH and were further treated by irradiation, GH levels decreased below 10 ng/ml after a 2-year period. In addition, in 3 out of 4 GH-secreting cases treated by irradiation only, GH levels decreased below 10 ng/ml after a 2-year period. Irradiation seemed effective in GH-secreting adenomas.
日本脳神経外科学会の論文
1979-10-15

下垂体腺腫例の内分泌学的検索 : 治療前より治療後長期follow upにおける下垂体機能障害の変遷について

スポンサーリンク

概要

著者

関連論文

スポンサーリンク